S01 / Design

System setup.

Designing and standing up a quality system framework from zero (greenfield) or from broken state. Triple-domain coverage in one engagement: bioanalytical, bioequivalence, clinical trials.

5 min read
You'll leave with: What it takes to stand up a regulated quality system from zero, and where most greenfield builds break.
/ Who this is for

The fit.

Organisations building a quality system from scratch — CRO operations leads, combination-product founders, post-incident rebuilds.

/ The work itself

What this delivers.

Architectural framework, governance substrate, cross-domain SOP scaffolding, implementation roadmap.

/ Why this matters

Where the edge is.

PQIOS architectural framework. Governance-substrate thinking. Triple-domain coverage in one engagement — most consultancies operate single-domain. Where domain edges blur (BA-BE handoffs, CT-device combination products), the cross-domain integrator role is rare.

/ How engagement runs

The shape of the work.

Every engagement is scoped per situation. The shape — focused diagnostic, structured implementation, ongoing partnership — emerges from the discovery conversation rather than a fixed package. Some engagements are short and intense; some are months-long structural builds; some are recurring quality oversight. We talk first, then scope.

01

Discovery.

Conversation to understand current state, target regulatory regime, organisational scale.

02

Scoping.

Phased proposal with deliverables aligned to regulatory inflections.

03

Build.

Architectural framework, governance substrate, SOP scaffolding aligned to operational reality.

04

Handover.

Documentation, training, post-handover support window for the first inspection cycle.

What to do next.

If this is the work in front of you, the next step is a conversation. I read every message and respond personally. No contact forms. No sales sequence. Just a discovery conversation to understand whether the fit is real, and what the shape of the work would be.

Cadence promise: I publish weekly on regulated AI governance. If a week is missed, the journal entry explaining why goes up in real-time.